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Antidepressants and Sexual Function
There are several types of anti-depression drugs. Widely used are SSRIs(Selective serotonin reuptake inhibitors) and SNRIs(Serotonin-norepinephrine reuptake inhibitor). Usually anti-depression drugs cause excessive chronic prolactin production, this condition is called Hyperprolactinemia (smtms. miswritten hyperprolactimia) and can best be described as a functional disorder. Excessive prolactin in the bloodstream reduces the testosterone and DHT release from the testicles, thus resulting in bone and muscle weakness.
Additional function of the SSRIs is to block the dopamine nervous function in the hypothalamus-pituitary axis, which is responsible for the release of oxytocin (which is known as the emotional and orgasm hormone). The drugs also tend to indirectly interfere with all the neurotransmitter systems and the production of various hormones (usually by overloading the liver P45 detoxification ststem). They also block the spinal nervous transmissions in the synapses with a flooding of serotonin (due to the re uptaking inhabitation action). The gene expressions of D2 dopamine receptors, acetylcholine receptors and 5-HT (Serotonin) 2C receptors are also being alternated.
SSRIs will destroy the pituitary and liver functions, thus killing your proper sexual function. SSRIs only inhibit the re-uptaking of serotonin, but actually the natural levels of serotonin decrease due to the destruction effects on the liver P450. SSRIs drugs will most probably reduce the serotonin nervous action in the neuromuscular ending receptors all over the body.
Usually the blocking of dopamine and acetylcholine transduction accompanied with the high level prolactin, which is being dumpled into the bloodstream, disables the nervous function in the penis, disables the seminal production, and if taken systematically can completely desensitize the penile nerves, prostate and seminal vesicles. Furthermore SSRIs drugs tend to block hypothalamic/adrenal - dopamine-norepinephrine conversion and oxytocin release (essential to activation of the orgasmic contraction). All this means that there is a high chance that you will never achieve proper orgasm.
SSRIs anti-depression drugs cause neuroplasticity, which is a term for a deformation of synapses and outgrowth of serotonin neurons. This neuroplasticity is known to cause addiction and severe withdrawal symptoms. The SSRIs inhibit the reputaking of serotonin in the nervous synapse by blocking the serotonin transporter, thus allowing the serotonin neurotransmitter to continue influencing the postsynaptic neurons. However we may clearly understand that SSRIs are not increasing neurotransmitter synthesis, on the contrary - they are cutting down natural serotonin release from the nervous terminals, it is just that SSRIs stimulate more serotonin neurons. SSRIs antidepressants also tend to alter the relationship between dopamine and serotonin signaling in the striatum, which will receive moderate serotonergic and rich dopaminergic innervation. This can be extremely harmful and may cause irreversible damage, because due to the inhibition of serotonin transporters, the dense striatal Dopamine Transporters can uptake serotonin into the dopamine terminals, which will destroy the dopamine nervous function responsible for the release of oxytocin, LH and FSH(all of the assosiated with testicular functions). Also a weak dopamine function will result in a high pituitary release of prolactin and disable sexual function completely.
To negate the ill effects SSRIs may cause, one must power his dopamine, cholinergic, serotonin and GABA nervous function. The dopamine is essential to the hypothalamus-pituiatry-testicular function.