Cure-Erectile-Dysfunction.org

Chronic anxiety is an indicator that there are modulation disorders of Serotonin and GABA on the autonomic nervous system. It usually leads to overpowered nervous function. This in turn leads to premature ejaculation and performance anxiety.

Generally the Serotonin and GABA modulate the noradrenergic - sympathetic nervous function in two ways:

• By modulating the ANS - Autonomic Nervous System via direct norepinephrine neurons of the hypothalamic locus coeruleus (LC)
• By modulating the neuroendocrine humoral outflow via the hypothalamic-pituitary-adrenal axis.

The Serotonin, GABA and endorphin nervous control can reduce the seminal vesicles, prostate, and penile nervous' sensitivity. Also the GABA-eriginic nerves control the noradrenergic firing in the LC while the serotonin-ergic nerves reduce the noradrenergic-sympathetic nervous function. GABA-eriginic and serotonin-ergic nerves can also modulate the somatic and sympathetic nervous sensing by using beta-endorphin release.

Sexual stimulation, or orgasm ignites conversion of dopamine-norepinephrine in the hypothalamus and adrenal medulla, after that norepinephrine (NE) neurons of the locus coeruleus (LC) are activated. Also a synthesis of prostaglandin E2 is stimulated by the Norepinephrine (by activating a group of proinflammatory cytokines, such as: IL-1(alpha), TNF(alpha), IFN(alpha), IL-1B, IL-6, and MIP-1). Prostaglandin E2 sensitizes the sympathetic nerves in the adrenal glands, seminal vesicles, testicles, penis and prostate for the norepinephrine release. The norepinephrine release, in turn, triggers the neuroimmunotransmitters cytokins, prostaglandin E1 and additional Prostaglandin E2 release. The release of Prostaglandins triggers nervous erectile mechanism (with the release of Nitric Oxide and cGMP) that leads to erection. However, high levels of Prostaglandin E2 may over-sensitize the sympathetic and somatic nerves located in the prostate, bulbourethral glands and penis, which in turn will inflame the organ and will cause numerous symptoms, such as: fast ejaculation (even within seconds) and precum leakage.