Peyronie’s disease is actually a collagen scar tissue formation inside the penis. In order to reverse the condition you have to understand the biochemical processes that caused it in the first place.

If you masturbate chronically or use penile enlargement techniques, there is a fair chance that you will injure your penis beyond the point of self repair. Over-masturbation, over-ejaculation, or other excessive stressors over-discharges the brain’s acetylcholine, dopamine, and serotonin nerves systems. An excessive Prostaglandin E-2 release into the blood and tissues is also observed. The biggest problem associated with overmasturbation or over-ejaculation is the deactivation of the Central Nervous System (CNS) that drives the hypathamalus and anterior pituitary the master of the endocrine function for hormonal production. It powers the entire endocrine function through the parasympathetic nervous division – the bioelectric backup battery. Over-maturbation or over-ejaculation fully consumes testosterone and leaves nothing to recharge the CNS and the parasympathetic backup battery.

The production of androgen hormones – DHEA, testosterone, androstenedione, DHT and pituitary oxytocin becomes too low (as a result of the exhausted pituitary-adrenal and testicular axis) to modulate inflammatory prostaglandin E2 release. Other excessive stress hormones – prolactin, cortisol, noepinephrine and epinephrine (adrenaline) can also induce excessive prostaglandin E2 release for weakened neuro-immunity.

Excessive stressors epinephrine or/and cortisol, prostaglandin E-2, medication or street drugs, excessive blood sugar, excessive prolactin and estrogen, alcohol, cigarette chemicals, deficiency of insulin, deficiency of oxygen, deficiency of androgen hormones (hGH, DHEA, testosterone, DHT and oxytocin), and deficiency of electrolytes will thin and harden (reduce the elasticity and expansibility of) the tunica albuginea and its sheathing spongy corpus cavernosa for erectile dysfunction, penile shrinkage and collagen scarring.

A mechanical penile damage will usually induce hardening and collagen scaring of erectile tissues upon expansion beyond the elasticity that the tunica albuginea can endure (for the repair needed).

One has to boost prostaglandins E-1/E-3 and Nitric Oxide (cGMP) release from the adjacent healthy erectile tissues to soften the collagen scar or prevent collagen scar formation. This will also heal the damaged penile elastic tissues, nerves and blood vessels in the tunica albuginea and its sheathing spongy corpus cavernosa.

Other possible treatments include:

  • prescribing or continuing palliative methods
  • surgery

Injections of various chemical agents into the plaques
Injections of various chemical agents into the plaques have been utilized in a number of patients. Through the side effects and not satisfactory results, the intervention is considered hazardous.

Radiation therapy
Radiation is aimed at the plaque to reduce pain, but does not affect the plaque itself in a substantial manner. Unwanted side effects or worsening of the disease may occur.

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