Excessive epinephrine, androgens, or oxytocin result in precum that contains heightened prostaglandin E2 levels, while the lack of serotonin and GABA nervous modulation on dopamine-norepinephrine-epinephrine nervous modulation, inflammatory hormonal release, and sympathetic function result in flooding of precum and premature ejaculation.

Over-masturbation/ejaculation harms the parasympathetic/sympathetic nervous function on the erectile mechanism with the flooding of excessive stress and inflammatory hormones. Excessive testosterone – DHT conversion, excessive prostaglandin E2 production, and excessive precum release are observed through the over-excitatory oxytocinergic nervous function due to the weak serotonin-GABA nervous modulation.

PC exercises or sexual stimulation create more precum by stimulating the prostate to produce additional oxytocin, additional testosterone – DHT conversion, and will heat up the seminal vesicles, prostate itself, and the bulbourethral glands.

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