Semen contains prostaglandins, proteins, minerals, vitamins, testosterone, insulin-like growth factor I, alpha2-macroglobulin, and human growth hormone. It also contains a lot of proinflammatory factors, such as: prostaglandin E2, polyamines, histamine, and cytokines. Present are also also anti-inflammatory factors, such as: prostaglaidin E1 and E3, but are overpowered (by the pro-inflammatory ones) through the need of immune suppression for the safe passage of the sperm through the ejaculation tract and survival in the vagina.

A constant blasting of the tissues and nerves with seminal fluids will result in immune suppression, inflammation, hypersensitivity, and infertility (due to the toxic effects of the inflammatory mediators on the sperm).

The seminal fluid neuro-immune qualities are essential to establish pregnancy. The prostaglandins and cytokines will bind into the target cells’ receptors in the cervix and uterus, which in turn will activate the pro-inflammatory response and cytokines. Semen will also modulate the neutrophil influx into the uterine lumen.

Poor semen may cause vaginal yeast infection, vulvodynia, vaginosis, or allergic responses in a woman’s vagina. The probability will be greater if the concentration of anti-inflammatory prostaglandins E1 and E3 and cytokines is low and is not capable to balance the inflammatory responses. Rough sex may also contribute to similar reactions due to the mechanical stimulation of cox-2 expression for additional prostaglandin E2 release.

Semen should not be fully discharged through multiple ejaculations. Resident semen into the seminal vesicles is needed to restore brain, nervous and testicular blood function, and proper blood circulation.

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