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First we must get familiar with the term "Neuroplasticity" - neuroplasticity is an alteration of a nervous system with the sole purpose to adapt to certain inputs. Neuroplasticity is referred to the brain rewiring in response to changes in environment, experience or brain chemistry. It is essential to learning and memory. Neurons, if stimulated, will release neurotrophins - also known as nerve growth factor(NGF) and brain derived neurotrophic factor(BDNF). Neurotrophic factors are capable of regrowing damaged neurons. BDNF can mediate the neuroplasticity and influence learning, cognitive behavior, and memory.

A chronic sexual over-stimulation will induce over-release of BDNF, which will alter the brain and the synaptic plasticity and lead to addictive behavior. The neuronal plasticity will weaken the parasympathetic, vegal, and serotonin and GABA nervous modulation and control over the adrenergic, noradrenergic, and sympathetic nervous function. The over-stimulation on certain nervous systems and functions as the dopaminergic, noradrenergic, and glutaminergic will modify the brain function and lead to addiction and psychological disorders.

Depending on what is one's goal in life may differentiate the neuroplasticities as positive or negative ones. In cases of sexual exhaustion the sufferers have developed a very negative neuroplasticity of the brain, which leads to severe addiction to sexual activities, that when challenged will create withdrawal symptoms, both physiological and psychological.

Sexual addiction is due to neuroplasticity of the PVN (Hypothalamic paraventicular nucleus) where we observe innervations of different nervous components and systems - noradrenergic(norepinehprine), oxytocinergic, adrenergic(epinephrine), autonomic(parasympathetic and sympathetic), dopamin, acetylcholine, glutamate, vagal, Nitric Oxidergic, Serotonin, and GABAergic. The nervous remodeling itself occurs under the frequent stimulation of prostaglandin E2, oxytocin, and norepinephrine, while the serotonin and GABA nervous modulation are too weak to modulate the dopamine-norepinephrine-epinephrine conversion and control the norepinephrine firing. Norepinephrine activates certain cytokins and protein kinases in the Locus Caruleus for prostaglandin E2 production, which along with oxytocin lets you feel high and aroused. The enzyme dopamine beta-hydroxylase(increased by sex or masturbation) will constantly convert dopamine to norepinephrine to keep you in constant sexual thoughts and arousal, leading to addiction. Prostaglandin E2 if in excessive amounts is considered extremely harmful. However, it is vital for the regulation of the synaptic activity and plasticity, it actually accelerates the neuroplasticity. You need prostaglandin E2 for learning, and memory. Proper levels of prostaglandin E2 can be used for many things and will promote great results, if you study hard your brain will adapt to memorizing the concents in a short time because of the release of prostalgandin E2 and norepinephrine. If you use prostaglandin E2 for sex, though, you will end up severely addicted, and will have extreme difficulties to discontinue, since your brain is already wired. High levels of prostaglandin E2 will also enhance the cell membrane excitability and degrade the short term memory and spatial navigation. Moreover, excessive cortisol will inhibit the neurogenesis in the dentate gyrus, thus impairing the hyppocampus-dependent learning and memory abilities.

In order to reverse the negative neuroplasticity to a positive one, one must be self conscious of what he is doing, and break the cycle of psychological and physiological excitation by enhancing the proper modulation on certain conversions.