Excessive sexual activity discharges the brain's supply of acetylcholine, dopamine, serotonin, and GABA. This results in nervous, liver, kidney, cardiovascular, and endocrine disorders. Norepinephrine-epinephrine-sympathetic nervous fire occurs, along with a heightened levels of prostaglandin E2, histamine, cortisol (too high or too low) and glutamate.
The neuro-endocrine system, if over-discharged, won't recharge by itself. Inflammatory byproducts will then damage or burn out numerous nervous cells, leading to some of the symptoms described. This state usually affects one's hypothalamic-pituitary-adrenal-testicular axis (in the cases it doesn't, a condition called Persistent Sexual Arousal Syndrome (PSAS) is usually present). The production of vital androgen hormones, such as: androstenedione, testosterone, DHEA, and DHT, plus the pituitary oxitocin become too low to support neuro-immune function, responsible for the suppressing of the inflammatory hormone prostaglandin E2 release.
The inflammatory hormones - cortisol, prolactin, epinephrine, and norepinephrine, being excessive, will disable one's pituitary-testicular axis for a few days, weeks, or in the severe cases, even months. This will lengthen the refraction time, leading to a chronic sexual exhaustion and strange inflammations. Prostaglandin E2 will also be released from the tissues, leading to excitotoxicity in the brain cells, heart, lungs, liver, kidney, blood vessels, digestive system, prostate, gallbladder, pancreas, and testicles.
Since the semen is full of chemicals, the ones who over-ejaculate will lack zinc, calcium, citric acid, androgen hormones, spermine, potassium, fructose, phosphorylocholine, free amino acids (glycine, agmatine 5-HTP, and GABA), prostaglandinds E1 and E3, and numerous supporting enzymes.
During the sexual activity, one may experience pro-inflammatory responses to the induced epinephrine-norepinephrine conversions. Lowered levels of DHEA, testosterone, androstenedione, DHT, and oxytocin, are also usually observed up to several hours or even days in the moderate to severe cases.
If one continues with the ill practices and lifestyle, the suppression of androgen hormones by the excessive cortisol and prolactin, along with the constriction the arteries in the brain, adrenal glands, lived, and testicles, will result in weakened neuro-immune reactions to pro-inflammation, thus a prolonged recovery time will be observed.
Note that excessive Prostaglandin E2 will also cause weak neuro-immunity.
As a result of all of the above, sexual exhaustion produces multiple symptoms, with a great number of doctors failing to identify the root of the problems completely.
Symptoms of Sexual Exhaustion include but are not limited to:
Memory loss - in the form of attention deficiency or/and losing memory, and mind concentration. This is caused primarily by a deficiency of the neurotransmitters serotonin and acetylcholine, responsible for the memory protection.
Headaches or migraines - due to excessive release of the inflammatory hormone prostaglandin E-2, accompanied with excessive dopamine-norepinephrine-epinephrine conversions in the brain (as a result of the exhausted the acetylcholine, serotonin and GABA nervous systems).
Tiredness and exhaustion - low levels of dopamine, and excessive prolactin to shut down the testicular function, leading to failure in the parasympathetic nervous recharging system.
Weakness in the muscles - due to deficiency of testosterone, DHEA, and DHT.
Parkinson's symptoms (muscle tremors or twitching) - through acetylcholine and dopamine deficiency.
Premature ejaculation - due to the low levels of serotonin and acetylcholine, accompanied with a damage of the prostate and urethral nerves.
Hair Loss - due to the excessive burning to DHT.
Low libido - through locked hypothalamic-pituitary-adrenal-testicular axis, high levels of prolactin, and deficiency of acetylcholine, dopamine, serotonin, and oxytocin.
Vision Problems and Eye Floaters - due to disorders in acetylcholine and dopamine nervous circuits. A deficiency of proper serotonin-GABA nervous modulation in the retina, poor retinal blood circulation, and arterial constriction.
Ear buzzing or ringing - due to a deficiency of normal nervous modulation.
Ejaculation pains or cramps in the pelvic cavity(low back, low abdomen, tail bone, penis, testicles, head) - due to a lack of prostaglandin E-1 in the local tissues, accompanied with unstable levels of acetylcholine, dopamine, serotonin, and GABA.
Depression and mood swings - due to unstable levels of all the vital neurotransmitters - acetylcholine, dopamine, serotonin, and GABA.
Watery ejaculation or even lack of ejaculation - due to weaked liver, adrenal, prostate, and testicular function.
Weak erection or youth impotence - due to locked hypothalamic-pituitary-adrenal-testicular axis for lowered levels of androgen hormones.
Prostatitis - due to excessive inflammatory Prostaglandin E2 production.
Penile shrinkage - due atrophy in the spongy tissues, lack of androgen hormones, and excessive stress hormones in the sympathetic alpha receptors.
Penile bending - due to excessive collagen release for scar tissues, and nervous abrasion.
Irregular cardiovascular output - due to the weakened acetylcholine-serotonin and parasympathetic-vagus nervous function.
Sleeping disorders - due to lack of GABA and serotonin.
Frequent urination or urinary urgency - due to inflammatory responses.
Excessive Sweating - due to a constant dopamine-norepinephrine-epinephrine conversion.
The symptoms can worsen with time.
The solution is to improve your neuro-endocrine functioning and stabilize your serotonin and GABA nervous modulation on the "Fight or Flight" responses. One must also recharge his parasympathetic nervous system and boost prostaglandin E-1 , E-3, oxytocin, and Nitric Oxide availability for healing.