Chronic anxiety is indicative of modulation disorders, primarily related to Serotonin, Dopamine, GABA, and Acetylcholine on the autonomic nervous system. It usually leads to overpowered sympathetic nervous function, which in turn frequently leads to performance anxiety and premature ejaculation.

Generally speaking, Serotonin and GABA modulate the noradrenergic – sympathetic nervous function in two ways:

  • By modulating the ANS – Autonomic Nervous System via direct norepinephrine neurons of the hypothalamic locus coeruleus (LC)
  • By modulating the neuroendocrine humoral outflow via the hypothalamic-pituitary-adrenal axis.

Serotonin, GABA and endorphin nervous control can reduce prostate, seminal vesicles, and penile nervous sensitivity. Also, the GABAergic nerves control the noradrenergic firing in the LC while the serotoninergic nerves reduce the noradrenergic-sympathetic nervous function. GABAergic and serotoninergic nerves can also modulate the somatic and sympathetic nervous sensing by using beta-endorphin release.

Sexual stimulation or orgasm ignites conversion of dopamine-norepinephrine-epinephrine in the hypothalamus and adrenal medulla – Norepinephrine (NE) neurons of the locus coeruleus (LC) are then activated. A synthesis of prostaglandin E2 is stimulated by Norepinephrine (by activating a group of proinflammatory cytokines, such as: IL-1(alpha), TNF(alpha), IFN(alpha), IL-1B, IL-6, and MIP-1). Prostaglandin E2 sensitizes the sympathetic nerves in the adrenal glands, seminal vesicles, testicles, penis and prostate for norepinephrine release. The norepinephrine release, in turn, triggers the neuroimmunotransmitters cytokins, prostaglandin E1 and additional Prostaglandin E2 release. The release of Prostaglandins triggers nervous erectile mechanism (with the release of Nitric Oxide and cGMP) leading to erection. However, heightened levels of Prostaglandin E2 may over-sensitize the sympathetic and somatic nerves located in the prostate, bulbourethral glands and penis, which in turn will inflame the organ and will cause numerous symptoms, such as: fast ejaculation (even within seconds) and precum leakage.