Men may experience headaches, pains and cramps during sexual arousal, during ejaculation, or in post-orgasm or post-ejaculation for many hours or days.

Prolonged sexual activity will burn out acetylcholine, serotonin, dopamine and androgen hormones (testosterone, DHEA, androstenedione) in the brain. It will also elevate the levels of cortisol in the blood and stimulate dopamine-norepinephrine-epinephrine conversions. This elevation will induce an excessive release of prolactin, epinephrine and oxytocin, where the oxytocin and epinephrine are to cause tissue volume expansion or engorgement. Cortisol – prolactin – epinephrine will trigger COX-2 and PKS over-expression, leading to excessive prostaglandin E-2, thus resulting in nervous-arterial inflammation.

Prolactin and epinephrine (in the sympathetic nerves alpha-2 receptors) will produce a continuous contraction against the nerves that will, at that time, lack the vital prostaglandin E1 for elasticity and relaxation for persistent pains and headaches. The lack of prostaglandin E1 will result in a constant tightness and rigidity of tissues, blood vessels and nerves firing post-orgasmic states. With the additional release of prostaglandin E2, one will suffer various symptoms for as long as the prolactin and epinephrine are at what’s considered abnormal levels and ratio to other hormones. Some of the symptoms may be blurred vision, eye redness, post sex ear ringing, and eye floaters.

A persistent elevation of prostaglandin E2 may indicate that the testicular function is too exhausted – a burn or pain in the testicles is usually experienced.

If one engages in overly-active sexual activities, a change in the cerebrospinal fluid (CSF) will be present. This is so because any chemicals in the bloodstream can diffuse through the Blood-CSF barrier in the choroid plexus of the vestibular system. One should avoid drinking alcohol during times of harmful substances in the blood. The alcohol in the bloodstream passes through the Blood-CSF easily. This is exactly why it is so harmful to mix excessive sexual activities with drinking. Prostaglandin E2 will also damage or loosen the Blood-CSF. If you have inflammatory pains, you must stop drug abuse since the chemicals can easily pass into the CSF under this condition. You also must make sure that your blood doesn’t contains any neurotoxins.

Headaches after orgasm are usually a result of excessive dopamine-norepinephrine-epinephrine conversions that take place in the hypothalamus and hippocampus. The norepinephrine triggers excessive prostaglandin E2 production in the adenergic aplha and beta receptors of the noradrenergic receptors in the brain. Post-orgasm headaches occur when orgasm induced norepinephrine-epinephrine-prolactin release starts to constrict the arteries in the brain (this is done via the alpha receptors in the arteries that will lack E1 and E3). The arterial constriction will continue until the serotonin, vagal and GABA nervous function regain their control on the dopamine-norepinephrine-epinephrine conversion and restore the dopamine-hypothalamus-pituitary-adrenal and testicular axis (that will elevate the dopamine, oxytocin, androstenedione, testosterone, DHEA and DHT production), thus reducing the levels of cortisol, prolactin, norepinephrine and epinephrine. For sexually exhausted men this process can last anywhere from several days to even months.