The MDMA(Ecstasy) will break the serotonin vesicles (which are supposed to release serotonin gradually) in the axon terminals. A sudden rise of serotonin will be then observed and the short-circuitry for the proper serotonin nervous transmission will interrupt the sympathetic nervous circuits associated with certain responses as the “fight of flight” or ejaculation. MDMA will also increase the norepinephrine, epinephrine, and dopamine levels in the nervous synapses, thus resulting in brain orgasmic fires even if there is no real stimulation. MDMA will also put dopamine into the serotonin terminals with the use of the serotonin reuptaking transporters. Dopamine itself is toxic to the serotonin cells and terminals and will actually break down by MAO and turn into hydrogen peroxide, which will oxidize serotonin neurons.
MDMA(Ecstasy) will burn out the serotonian neuron axon terminals, especially if used more than several times a month for several months and the interneuron electric couplers will no longer serve the interconnection of acetylcholine, serotonin, dopamine, and GABA. The nervous circuits of parasympathetic-acetylcholine nervous communication will be partially interrupted. The faulty serotonin-GABA nervous modulation on the sympathetic function will lead to premature ejaculation and excessive dopamine-norepinephrine-epinephrine conversions for additional stress, ADD, anxiety, and other disorders. One may also lose libido due to numerous factors.
If one lets MDMA burn the serotonin in the synapses he/she will experience problems and will have hard time recovering. However, if strongly committed to using MDMA, one should supply the organism with enough “fuel” in the form of 5-HTP and numerous vitamins and amino acids.