Erectile Dysfunction (ED) is the repeated inability to get or keep an erection firm enough for sexual intercourse. There are different variations of Erectile Dysfunction – it may be a total inability to achieve erection or a tendency to sustain only brief erections.

The very process of achieving erection involves numerous nerve impulses to/from the brain, muscles, spinal column, fibrous tissues, arteries, veins and corpora cavernosa. Common causes for ED are damage to the nerves, smooth muscles, arteries, veins, or fibrous tissues. Sexual Exhaustion is also a syndrome tightly related to Erectile Dysfunction.

Bellow is described part of the relation between chronic over-active sexual activities and Erectile Dysfunction.

Over-masturbating/over-ejaculation at young ages consumes too much Human Growth Hormone, testosterone, and DHEA. It also discharges the central nervous system’s potential, loads too much stress and DHT hormone in the prostate, and kills the brain function responsible for driving the endocrine system to produce certain hormones and neurotransmitters.

The result of the additional DHT and testosterone receptors in the prostate is premature ejaculation (due to the over-enlargement and the excessive burning of testosterone in the prostate). High levels excitatory / stress hormones in the prostate can trigger (in this particular context) “Flight and Fight” – “Erection Withdrawal and Ejaculation” at the same time for premature ejaculation.

Over-ejaculation and/or over-masturbation first melts down the acetylcholine-parasympathetic nervous functions and then the liver functions that release essential enzymes for the syntheses of acetylcholine, dopamine and serotonin. It (over-ejaculation and over-masturbation) results in additional and excessive dopamine-norepinephrine-epinephrine conversions for extremely sympathetic nervous system functioning. The result is nervous dysfunctions, stress, anxiety, impatience, eye floaters or fuzzy vision, buzzing (noisy) ears, cardiovascular irregularities, urinary incontinence, prostatitis, weak kidney functions, pains or cramps in the pelvic cavity or/and tail bone, weak muscles or ligaments, and so on.

In addition, semen consists of high concentrations of potassium, calcium, zinc, magnesium, citric acid, phosphorylcholine, fructose, spermine, prostatic acid phosphatase, free amino acids, prostaglandins and enzymes, which nourish and protect the sperm. Semen also contains a lot of GABA and beta-endorphin, both of which are calm-inhibitory neurochemicals. When a healthy man ejaculates, he triggers the glutamate-GABA conversion with the liver enzyme glutamate decarbozylase. The cerebrospinal fluid (CSF)s GABA and asparagine-glutamate concentrations increase with 100% and 200%, while there are also small decrements of amino accids such as serine, arginine, alanine and leucine present. If glutamate decarbozylase (a liver enzyme) is lacking, glutamate in CSF becomes too high and GABA becomes too low. This is why ejaculation causes a deficiency of GABA and excessive glutmamte for brain / nervous instability and sympathetic nervous “Fight or Flight” responses. Also, persistent sexual arousal can be observed if a person lacks GABA and beta endorphin, but has high level of dopamine, glutamate, epinephrine, norepinephrine, and/or histamine. A person lacking GABA, serotonin and beta-endorphin will experience severe anxiety, depression, mood swing, de-realization, irritation, panic responses, premature ejaculation, penile over-sensitivity, and pains. Over-masturbation, excessive sex, excessive orgasms or drug abuse can also induce brain arterial inflammation, which will narrow down the arteries and constrict the blood flow to the brain. The narrowed arteries in the brain will require higher blood pressure which will result in hypertension, headaches, migraines, gum inflammations, blurred version, sleeping disorders, ear ringing, body or joint pains, inflammation, liver and kidneys fires, and prostate-bladder-urethral disorders.

Overmasturbation or ejaculation constricts arteries and creates inflammatory narrowness in the brain and plevic organs (testicles, prostate, seminal vesicles and penis) due to excessive release of prolactin, norepinephrine, and epinephrine, and excessive binding of norepeinephrine-epinephrine on the alpha-adrenergic receptors. Excessive prostaglandin E2 is released then into the bloodstream and a deficiency of nitric oxide and prostaglandins E1 E3 occurs. All this castrates the hypothalamus-pituitary-testicular axis. Once the hypothalamus-pituitary-testicular axis is locked, one will lack the essential androgen hormones – DHEA, testosterone and DHT to unlock it. To prevent the castration effects, one will have to keep the blood flow to the brain and testicles after having sexual activities and experiencing sex-induced stress. To keep arterial dilation via nitric oxide and cGMP releases from the vegal-parasympathetic nervous endings, one needs post-sex androgen hormones and oxytocin.