Chronic over-masturbation/over-ejaculation trains the prostate ejaculation control nerves to ejaculate as soon as the dopamine-sympathetic-sensory nervous circuits are stimulated. It is a reflexion training. Some of the sufferers get prostates nervous relexion training in response to any sexual stimulation from vision, hearing. kissing, to touching. They must de-train the prostate’s nervous plasticity.

Here is a list of the most common causes for premature ejaculation:

  • Using Kegel Exercises to support the erection, which involves the PC muscles.
  • Prostate PC muscles fatigue.
  • Poor blood circulation, leading to trapped excessive DHT, norepinephrine, epinephrine, glutamate and histamine.
  • Prostate abrasion and fast-ejaculation training.
  • Excessive norepinephrine, epinephrine, histamine, and glutamate which lead to nervous toxicity, performance anxiety and penile hypersensitivity.
  • Drug abuse – either street or medication drugs.
  • Parasympathetic, Serotonin and GABA nervous control disorders.
  • Erectile dysfunction.
  • Penile, testicle or prostate surgery.
  • Excessive inflammatory hormone prostaglandin E2 in the bloodstream, penis, semen, prostate or even your partners vagina.
  • Excessive semen accumulation in the seminal vesicles, which exerts pressure against the prostate and induces pelvic congestion and pain.
  • Long-term semen retention or abstinence, leading to excessive prostaglandin E2 and/or excessive testosterone.
  • Excessive oxytocin in the bloodstream.
  • Excessive or insufficient dopamine nervous excitation, associated with the hypothalamic-pituitary-testicular axis and thyroid functioning.
  • Excessive or insufficient testosterone and DHT, associated with penile erectile nervous stimulation and inflammatory prostaglandin E2 production.
  • Liver functional disorders, affecting the abnormal syntheses of the androgen hormones, thyroid hormones, and neurotransmitters.
  • Excessive or insufficient testosterone and DHT, associated with penile erectile nervous stimulation and inflammatory prostaglandin E2 production.
  • Pineal gland disorders or melatonin deficiency (sleeping disorder), associated with the recharging of the parasympathetic nervous system during sleeping, the pituitary hGH production, and the serotonin, GABA and norepinephrine nervous function.
  • Neuro-endocrine disorders.
  • Concentration of ions (Na-K, Cl) and permeability characteristics of the nervous cell membrane.
  • Genetic Tetrahydrobiopterin (BH4) deficiency, which will lead to dopamine and serotonin nervous disorders.

Chronic stimulation of sex organs can lead to over-production of a-MSH. It also traps excessive a-MSH in certain areas of the skin, which may result in extra skin darkness, particularly in eye cycles, labia minors, and penile foreskin. Chronic over-masturbation also leads to over-reactive or also called over-trained prostate, PC muscles, and bulbourethral glands.

Destruction of serotonin and GABA nervous control, exhaustion of the hypothalamus-pituitary-adrenal and testicular axis and liver system results in an unbalanced release of pro-opinomelanocotin (POMC) peptides, such as AdrenoCorticoTropic Hormone (ACTH), endorphins, a-Melanocyte-Stimulating Hormone (a-MSH), and Lipotropin Hormone (LPH). Also, prostate abrasion, excessive inflammatory hormone prostaglandin E2 production, excessive stress hormones cortisol and epinephrine for performance anxiety, parasympathetic and sympathetic erectile nervous disorders, excessive use of PC muscles, and precum/semen leakage will be observed. When the serotonin, GABA, endorphrin, cortisol, and/or a-MSH fail to modulate the dopamine – norepinphrine conversion and the psychological stressors norepinephrine/epinephrine-induced inflammatory hormone prostaglandin E2 production, one may observe more than one of the following responses to sexual stimulation:

  • Excessive dopamine-norepinephrine induced prostaglandin E2 for a core temperature rise (over-heating or “sex fever”) in the brain, spine, adrenal glands and prostate – the sympathetic nervous “Fight and Flight” responses.
  • Prostaglandin E2 over-excited penile and prostate nerves for penile and prostate hypersensitivity.
  • Excessive prostaglandin E2 induced prostate and bulbourethral inflammatory responses and over-heating for precum and semen leakage, plus instant ejaculation.

Premature-ejaculation’s most common causes, including drugs, surgery, genetic disorders, and other organ functional disorders.