Propecia (Finasteride), a commonly-prescribed drug treatment for androgenetic alopecia, is hazardous to one’s neuro-endocrine functioning and can lead to Sexual Exhaustion.

How is Propecia leading to Sexual Exhaustion?

Propecia affects an enzyme called 5 Alpha Reductase which is responsible for Testosterone to DHT conversion. This immediately results in somewhat higher Testosterone and lowered Dihydrotestosterone (DHT) levels. The usual percentage of alteration is about 15 to 20%, which may seem low but in the context of proper organism functioning is actually extremely significant. The manufacturer’s notion that DHT is an insignificant hormone and can be inhibited without serious consequences is completely false. DHT is an androgen times more potent than Testosterone and is directly responsible for:

• Male Libido
• Fertility
• Prostatic size and function
• The health integrity of penile tissues
• Nitric Oxide levels
• Estrogen levels

It also directly affects numerous hormones responsible for proper hypothalamic-pituitary-adrenal-testicular axis functioning like Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH). Administration of Propecia will immediately alter LH – FHS – Testosterone – DHT ratio.

The Result?

The mentioned phenomenon will result in a rather violent tissue alterations on a biochemical level. Prostatic, penile, and sexually related tissue fragility and loss is expected. It, in turn, will result in decreased semen volume, decreased penile size and fibrosis (firm flaccid penis and possible peyronie’s disease), and erectile dysfunction. The loss of elasticity could also result in a further abrasive damage through forceful low quality prostaglandin E2 filled semen ejaculatory contractions. Nerve damage has frequently been documented as well.

5 Alpha Reductase has been known to be closely involved in the biosynthesis of inhibitory neurosteroids. In fact, it’s only 5α-reductase type I and 3α-hydroxysteroid dehydrogenase that are involved in the synthesis of all the inhibitory neurosteroids.

Inhibitory neurosteroids act as inverse agonists of GABA(a) receptors and other neurotransmitters involved in inhibitory actions on neurotransmission. This means that 5 Alpha Reductase is actually directly needed for the proper serotonin – GABA nervous modulation on excitatory and inflammatory response.

Inhibitory neurosteroids possess anxiolytic, stress-reducing, prosocial, anaesthetic, prosexual, and antidepressant effects. Not surprisingly, neurosteroids have been proven to be involved with neuroplasticity, memory, behavior, and responses to stress, depression, and emotions.

The connection between 5 Alpha Reductase and neurosteroid biosynthesis is unquestionable, as it is the effects these neurosteroids on one’s physical and mental health.

Post-Finasteride Syndrome caused by Propecia explained

In many instances, Propecia won’t actually lead to any notable side effects. This is true predominantly for individuals who didn’t suffer from any of the stages of Sexual Exhaustion prior to administration of Propecia.

Men that were affected by stages of Sexual Exhaustion before taking Propecia are the ones that usually experience the worse side effects. It is so through the inability of one’s organism (in it’s already exhausted state) to cope with the percentage of alteration caused by Propecia. Post-Finasteride Syndrome is, in fact, a variation of Sexual Exhaustion.

Post-Finasteride Syndrome symptoms include:

• Erectile Dysfunction
• Loss of Libido
• Low Testosterone, LH, FSH, and other vital androgens
• Penile Shrinkage
• Penile Fibrous Plague
• Hormonal Imbalances
• Depression
• Fatigue
• Cognitive Impairment
• Memory Impairment
• Sleep Disturbances
• Muscle Atrophy
• Increased Inflammatory Responses
• Emotional Blunting and Depersonalization

Sexual Exhaustion, combined with a sharp lowering of neurosteroids and androgens (as a result of Propecia) will lead to a “breaking point” and a cycle of inflammation. At this point, it’s extremely difficult for an organism to recover by itself.

It’s important to understand that Post-Finasteride Syndrome is a self supporting cycle through:

1.) Lowered and, more frequently than not, imbalanced levels of dopamine, serotonin, acetylcholine, and GABA, which results in a deranged organism functioning and a wide range of symptoms. The most notable consequence of this is, however, the inadequate serotonin – GABA nervous modulation on excitatory and inflammatory response. Naturally, this results in excessive excitatory – inflammatory responses which are actually acting as a catalyst for the creation of a negative neuronal plasticity. This effect comes as a consequence of the once handy quick and effective organism behavioral modulatory adaptation during times of extreme external stressors (wild animals and threats that needed fast and prolonged behavioral adaptation on neuronal level).

To sum it up – inflammation caused by sympathetic functioning overdrive will create a negative neuroplasticity extremely fast. This will lead to extreme difficulties as far as proper positive neuroplasticity restoration goes.

2.) Adrenal gland adjustments to chronically create more stress and inflammatory hormones, at the expense of DHEA.

3.) Mild to moderate artery constriction (due to constant sympathetic functioning) for less blood and even increased inflammation.

4.) Lowered neurosteroids, combined with increased inflammatory norepinephrine, epinephrine, prostaglandin E2, cortisol, and prolactin to negatively affect the levels of GnRH, LH, and FHS and together with arterial inflammation and constriction kill hypothalamic – pituitary – adrenal – testicular functioning.

5.) Low androgen levels to insufficiently modulate energy levels, tissue and testicular health, numerous hormonal conversions and proper neurotransmitter homeostasis will result in a vicious cycle of inflammation to suppress them even further.

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So, what is Sexual Exhaustion?

First and foremost, it’s important to understand that Sexual Exhaustion is a syndrome. The term syndrome is defined as a a group of symptoms that consistently occur together or a condition characterized by a set of associated symptoms.

Sexual Exhaustion is not only referring to sexual performance and abilities as is the common misconception. The term was first used as a description of sexual activities, frequently over the top, resulting in numerous ill consequences involving wide array of systems, organs, and tissues all the way to the base of their very functioning with various hormones, neurohormones, and neurotransmitters being seriously affected.

Why is getting better frequently so difficult to achieve?

Somewhere along the road of exhaustion, one usually develops a negative self-supporting neuroplasticity. It is a term used to describe inabilities of a given organism to restore itself to what’s considered to be a positive functioning only with the aid of its own hormones, neurohormones, and neurotransmitters.

Why are tests ineffective in detecting the imbalanced state?

Tests are usually ineffective in detecting the imbalanced state through the inability to monitor neurotransmitter levels in the brain, the wide range of acceptable results, and the flat ratio of hormone-neurohormone-neurotransmitter interactions monitored.

Are some people naturally predisposed to getting sexually exhausted more easily?

Yes, some people have been shown to be more susceptible to sexual exhaustion than others in similar physical and psychological circumstances. We shouldn’t neglect and general predisposition for exhaustion through certain receptor gene alterations. However, given the right circumstances, anyone can eventually exhaust his organism, reach the “breaking point” and basically get stuck in a cycle of inflammation.

Why is sexual exhaustion said to be a self-supporting syndrome?

There are numerous contributing factors but for the sake of relative simplicity we’ll concentrate on the major ones.

First:
Lowered or/and severely imbalanced levels of acetylcholine, serotonin, dopamine, and GABA levels leads to deranged organism functioning and a wide set of symptoms. However, the most notable consequence of this imbalance is arguably the chronically heightened stress response through inadequate serotonin-GABA modulation on neuronal activity. As a direct result, excessive cortisol and prostaglandin E2 in tissues and brain, once important for proper organism behavioral modulation and adaptation through times of acute stressor exposure, create the new negative neuroplasticity extremely fast.

Second:
Adrenal gland adjustments to chronically create more stress and inflammatory hormones, such as cortisol and epinephrine, at the expense of DHEA.

Third:
Artery constriction for less blood flow and thus increased local inflammation.

Fourth:
The increased levels of cortisol, prostaglandin E2, norepinephrine, epinephrine, and especially prolactin to negatively affect the levels of GnRH, LH and FSH, and together with the arterial inflammation and constriction kill hypothalamic-pituitary-adrenal-testicular axis’ proper functioning. Less androgens to modulate inflammatory response, testicular insulin resistance, energy levels, tissue and testicular health, hormonal conversions, and neurotransmitter homeostasis, will result in even more vicious cycle of inflammation to suppress them even further through low dopamine levels and chronically heightened prolactin. Overactive sexual activities will slowly drain an organism of its potential for rejuvenation.

Why is the range of symptoms so wide?

Every symptom and the underlined causes for the symptoms experienced is just a direct result of an ongoing process which involves mainly nervous and endocrine systems. You can see how this state may manifest in a wide range of symptoms through individual gene expressions. However, quite a few symptoms can mainly be contributed to improper serotonin-dopamine-acetylcholine-GABA ratio/levels for weakened nervous modulation on excitatory and inflammatory response and abnormal hypothalamic-pituitary-adrenal-testicular axis functioning for lowered androgens levels.

I know I’m suffering from Sexual Exhaustion, what can I do?

If you consider yourself to be suffering from the syndrome, despite being somewhat of a tricky one, there are many things that can be done in order to restore proper organism’s functioning.

The way to go is to transform your neuroplasticity to a positive one. The interneuronal connections have been developed and ordered to process information in a specific manner. You may experience severe difficulties in rewriting their work to induce proper, by what you consider a proper, responses in certain situations.

So, the first step is to create what you would consider a positive neuroplasticity and keep it for a prolonged period of time. You should definitely completely discontinue any alcohol, drugs, SSRIs/SNRIs usage as they frequently lead to numerous and severe issues. Remember that even after you discontinue those you still may have a hard time restoring your erectile quality through the negative neuroplasticity developed over the years.

It’s important to note that ideally every problem must be addressed simultaneously to avoid feedback reactions supporting the developed negative neuroplasticity. That’s why just a random set of products or supplements of any kind frequently prove to be ineffective.

For starters, there are some things you may consider doing, such as:

* Exercise
Running is very beneficial for Nitric Oxide and hGH boosts.
* Proper diet
Much fiber, fruits, avoid milk with prostaglandin E2 analogs, avoid empty calories and much red meat.
* Negative ion exposure
The general rule is wherever there is water, there are negative ions: rivers, lakes, oceans and ponds, even your own shower.
* Massages
Similar practices definitely have positive effect on local inflammatory processes and proper blood circulation restoration.
* Sexual activities discontinuation
You’ll also need to discontinue sexual activities for 1 to 2 months and then limit masturbation as well as other similar in nature activities to 1-3 times a week for 3 to 5 months.

These are vital steps and yet, as you may notice yourself, frequently not enough. There are some main points you’ll need to take care of:

You’ll frequently need to additionally improve nervous and endocrine functioning, stabilize acetylcholine, serotonin, dopamine, GABA levels, aid hypothalamic-pituitary-adrenal-testicular axis proper functioning, cleanse the liver and restore its P450 detox. system which is particularly important in cases with alcohol, drugs, or SSRIs/SNRIs involvement, restore proper serotonin-GABA nervous modulation on excitatory and inflammatory response, increase androgens, increase elasticity prostaglandins E1 E3 and Nitric Oxide, alter numerous gene expressions, and eventually rewrite the negative neuroplasticity developed.

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The very process of achieving erection involves numerous nerve impulses to/from the brain, muscles, spinal column, fibrous tissues, arteries, veins and corpora cavernosa. Common causes for ED are damage to the nerves, smooth muscles, arteries, veins, or fibrous tissues. Sexual Exhaustion is also a syndrome tightly related to Erectile Dysfunction.

Bellow is described part of the relation between chronic over-active sexual activities and Erectile Dysfunction.

Over-masturbating/over-ejaculation at young ages consumes too much Human Growth Hormone, testosterone, and DHEA. It also discharges the central nervous system’s potential, loads too much stress and DHT hormone in the prostate, and kills the brain function responsible for driving the endocrine system to produce certain hormones and neurotransmitters.

The result of the additional DHT and testosterone receptors in the prostate is premature ejaculation (due to the over-enlargement and the excessive burning of testosterone in the prostate). High levels excitatory / stress hormones in the prostate can trigger (in this particular context) “Flight and Fight” – “Erection Withdrawal and Ejaculation” at the same time for premature ejaculation.

Over-ejaculation and/or over-masturbation first melts down the acetylcholine-parasympathetic nervous functions and then the liver functions that release essential enzymes for the syntheses of acetylcholine, dopamine and serotonin. It (over-ejaculation and over-masturbation) results in additional and excessive dopamine-norepinephrine-epinephrine conversions for extremely sympathetic nervous system functioning. The result is nervous dysfunctions, stress, anxiety, impatience, eye floaters or fuzzy vision, buzzing (noisy) ears, cardiovascular irregularities, urinary incontinence, prostatitis, weak kidney functions, pains or cramps in the pelvic cavity or/and tail bone, weak muscles or ligaments, and so on.

In addition, semen consists of high concentrations of potassium, calcium, zinc, magnesium, citric acid, phosphorylcholine, fructose, spermine, prostatic acid phosphatase, free amino acids, prostaglandins and enzymes, which nourish and protect the sperm. Semen also contains a lot of GABA and beta-endorphin, both of which are calm-inhibitory neurochemicals. When a healthy man ejaculates, he triggers the glutamate-GABA conversion with the liver enzyme glutamate decarbozylase. The cerebrospinal fluid (CSF)s GABA and asparagine-glutamate concentrations increase with 100% and 200%, while there are also small decrements of amino accids such as serine, arginine, alanine and leucine present. If glutamate decarbozylase (a liver enzyme) is lacking, glutamate in CSF becomes too high and GABA becomes too low. This is why ejaculation causes a deficiency of GABA and excessive glutmamte for brain / nervous instability and sympathetic nervous “Fight or Flight” responses. Also, persistent sexual arousal can be observed if a person lacks GABA and beta endorphin, but has high level of dopamine, glutamate, epinephrine, norepinephrine, and/or histamine. A person lacking GABA, serotonin and beta-endorphin will experience severe anxiety, depression, mood swing, de-realization, irritation, panic responses, premature ejaculation, penile over-sensitivity, and pains. Over-masturbation, excessive sex, excessive orgasms or drug abuse can also induce brain arterial inflammation, which will narrow down the arteries and constrict the blood flow to the brain. The narrowed arteries in the brain will require higher blood pressure which will result in hypertension, headaches, migraines, gum inflammations, blurred version, sleeping disorders, ear ringing, body or joint pains, inflammation, liver and kidneys fires, and prostate-bladder-urethral disorders.

Overmasturbation or ejaculation constricts arteries and creates inflammatory narrowness in the brain and plevic organs (testicles, prostate, seminal vesicles and penis) due to excessive release of prolactin, norepinephrine, and epinephrine, and excessive binding of norepeinephrine-epinephrine on the alpha-adrenergic receptors. Excessive prostaglandin E2 is released then into the bloodstream and a deficiency of nitric oxide and prostaglandins E1 E3 occurs. All this castrates the hypothalamus-pituitary-testicular axis. Once the hypothalamus-pituitary-testicular axis is locked, one will lack the essential androgen hormones – DHEA, testosterone and DHT to unlock it. To prevent the castration effects, one will have to keep the blood flow to the brain and testicles after having sexual activities and experiencing sex-induced stress. To keep arterial dilation via nitric oxide and cGMP releases from the vegal-parasympathetic nervous endings, one needs post-sex androgen hormones and oxytocin.

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Wet dreams caused by normal biochemical occurrences will be present when the seminal vesicles are full of semen, and an additional burst in the seminal production is observed through the elevation of DHEA and testosterone.

Abnormal wet dreams generally have nothing to do with seminal production. They are a direct result of a sympathetic nervous response to the induced inflammatory hormone prostaglandin E2 and cortisol production during sleeping, while at the same time beta-endorphin, serotonin, and GABA nervous control fails to calm down prostates nervous ejaculation response to the excitation of prostaglandin E2 and Cortisol.

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Excessive sex induced stress hormones norepinephrine and epinephrine may damage retinal endothelial cells, inflame eye balls and retina, and dilate eye pupils.

There are several sex-induced eye or vision problems:

Eye Floaters

The deficiency of dopamine, serotonin, GABA, glycine, agmatine and androgen hormones (DHT, DHEA and testosterone) plus excess or deficiency of cortisol, norepinephrine, epinephrine and prolactin, may seriously damage visual sensor’s circuitry. The optometrists can’t detect quantities of them inside the eyeballs, steering the treatment to a wrong direction. Other symptoms may be present, such as: poor eye blood circulation, damaged eye capillaries, abnormal clearance of glutamate in certain photoreceptors in response to light, or even damaged photoreceptors that constantly release excessive glutamate to shut off the post-synaptic response to light.
When glycine (an inhibitory neurotransmitter in the central nervous system, brainstem, spinal cord, and retina) receptors are activated, chloride will enter the neuron via ionotropic receptors, causing the so called Inhibitory postsynaptic potential.

Redness

It’s caused by breakage of capillaries, inflammation by the excessive prostaglandin E2-norepinephrine-epinephrine and insufficient prostaglandin E1, mechanical damage, low cortisol, or excessive histamine.

Light over-sensitivity in the Retina
There is a circular opening located in the center of the iris that controls the amount of light that enters the eye. Excessive prostaglandin E2 (induced by excessive norepinephrine) and histamine in the retina, accompanied with lack of serotonin, glycine, GABA and prostaglandin E1, can over-excite the visual receiving sensors.

Melatonin is the main light sensitivity regulator. It is responsible for the photomechanical movement, cone photoreceptor and elongation and the contraction of different photoreceptors. Melatonin decreases when the light is decreasing, this is done to increase the photosensitivity of the receiving circuits, thus compensating the weak visibility by clearing the perception. Also, a dopamine is being released in the retina, but increases after light exposure and decreases in darkness. Melatonin is the darkness hormone while dopamine is the light hormone.

As a feedback control of the visual circuit, the photosensitivity of the receiving circuit decreases as dopamine increases, so that there is no truncation of visual signals entering the visual cortex. When the dopamine level is too low, though, the retinal receiving circuit becomes too sensitive to light. The eye pupils become dilated by the norepinephrine – sympathetic nervous function.

Melatonin also modulates the retinal pigment epithelium (RPE) function by aggregating pigmented cells in the RPE and choroid of the eye. Another way for melatonin to regulate the amount of light entering the photoreceptor is by controling the movement of melanosome granules within the RPE where melanosome granules store melanin. Melatonin can also alter the electrical activity of the RPE.

The darkness neurotransmitter is glutamate. It is modulated by the receiving circuit by decreases in its concentration. When we expose our eyes to light, it will take a while to turn on the color receiving circuit by removing glutamate. What is unfortunate is that dopamine and glutamate are essential to sexual arousal and orgasm. During sexual activity, the excessive glutamate turns into GABA, 5-HTP to serotonin, and the dopamine to norepinephrine. The result is an elevation of melatonin to suppress dopamine synthesis. In the more severe cases, the glutamate will not turn to GABA and the dopamine drops too low, leading to light-oversensitivity and eye floaters in the retina.

Blurred Vision and Central Serous Retinopathy

Numerous factors may contribute to these symptoms, such as:

• Excessive prostaglandin E2 and insufficient prostaglandin E1 in the eye balls.
• Excessive neuroexcitotoxic glutamate in the extracellular space of the retina, causing visual nervous damage
• Excessive epinephrine in the eye balls or/and excessive sympathetic nervous action, which will dilate the eye pupils
• Completely wrong eye balls chemistry – deficiency of DHEA, testosterone, DHT, excessive or insufficient cortisol and prolactin.
• Abnormal levels of acetylcholine and dopamine in the visual sensing circuits
• Acetylcholine deficiency or blockage, that will disrupt the retinal activities and visual signal output, leading to visual blackout, or even blindness.

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The excess of norepinephrine-epinephrine result in different abnormalities in the sympathetic nerve for: post-sexual activity anxiety, sleeping disorders, and high blood pressure. Other symptoms such as: asthma, ear ringing, headaches, eye inflammation, and difficult breathing also usually occur.

The inflammation spreads individually through different gene expressions and may affect numerous internal tissues and organs.

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Street drugs pollute the brain and nervous systems, alternate or destroy the gene expression of the nervous receptors or synapses. Neurodegeneration may occur, bringing its two widely known diseases – Parkinsons and Alzheimer. Mixing excessive sexual activity with street drugs is very dangerous. Over-ejaculation by itself is destructive enough – alternating the gene expression of dopamine receptors – D1 and D2, Serotonin C2 receptor, GABA A receptors and acetylcholine receptors.

Chronic use of street drugs will also directly damage testicular functioning and will interfere with the seminal production of the prostate.

The street or medication drugs also exert poisoning and damaging effect on the skins neuro-endocrine cells, and considering that the skin serves as a neuroendocrine organ for a production of neurotransmitters and hormonal production, the effect may prove to be devastating.

Liver is also heavily damaged by street drugs (nicotine, methamphetamine, cocaine), which leads to the destruction of liver’s detoxification system, thus leading to a reduction of ability to produce vital neurotransmitters and androgen hormones. One who uses street drugs is surely messing around with his dopamine, acetylcholine, serotonin and GABA nervous functioning.

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Nicotine is also associated with changes of the sperm membranes, receptors, and damage to the sperm DNA. By mimicking acetylcholine, it will bind to a sperm cholinergic receptor that is responsible for the sperm’s fertilizing properties.

Smoking will also result in abnormal increases of the seminals’ leukocyte counts by almost doubling it. An increased seminal leukocytic counts (white blood cells) is a clear sign of an ongoing inflammation within the reproductive tract, leading to poor quality and quantity of the semen. Smoking related oxidization stress explains the reduced sperm fertilizing capacity and increased oxidative damage to the sperms DNA among male smokers.

High levels of dopamine, serotonin and GABA nervous function will help one overcome nicotine addiction.

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A chronic sexual over-stimulation will induce over-release of BDNF, which will alter the brain and synaptic plasticity and lead to addictive behavior. The neuronal plasticity will weaken the parasympathetic, vegal, serotonin, and GABA nervous modulation and control over the adrenergic, noradrenergic, and sympathetic nervous function. The over-stimulation of certain nervous systems and functions as the dopaminergic, noradrenergic, and glutaminergic will modify the brain function and lead to addiction and psychological disorders.

Depending on what is ones goal in life, we may differentiate the neuroplasticities as positive or negative ones. In cases of sexual exhaustion, the sufferers have developed a negative neuroplasticity in the brain and body, leading to severe addiction to sexual activities, that if challenged, will create withdrawal symptoms, both physiological and psychological.

Sexual addiction is a result of neuroplasticity of the PVN (Hypothalamic paraventicular nucleus), where we observe innervations of different nervous components and systems – noradrenergic (norepinehprine), oxytocinergic, adrenergic (epinephrine), autonomic (parasympathetic and sympathetic), dopamine, acetylcholine, glutamate, vagal, nitric oxidergic, serotonin, and GABAergic. The nervous remodeling itself occurs under the frequent stimulation of prostaglandin E2, oxytocin, and norepinephrine, while the serotonin and GABA nervous modulation are too weak to modulate the dopamine-norepinephrine-epinephrine conversion and control the norepinephrine firing. Norepinephrine activates certain cytokins and protein kinases in the Locus Caruleus for prostaglandin E2 production, which along with oxytocin lets you feel high and aroused. The enzyme dopamine beta-hydroxylase (increased by sex or masturbation) will constantly convert dopamine to norepinephrine to keep you in a constant state of sexual arousal, leading to addiction. Prostaglandin E2, if in excessive amounts, is considered extremely harmful. However, it is vital for the regulation of the synaptic activity and plasticity since it actually accelerates the neuroplasticity. One needs prostaglandin E2 for learning, and memory. Proper levels of prostaglandin E2 can be used for many things and will promote great results. If one studies hard, the brain will adapt to memorizing the concepts in a short time through the release of prostalgandin E2 and norepinephrine. If one uses prostaglandin E2 for sex, though, will end up severely addicted, and will experience discontinuation difficulties since the brain has already been wired. High levels of prostaglandin E2 will also enhance the cell membrane excitability and degrade the short term memory and spatial navigation. Moreover, excessive cortisol will inhibit the neurogenesis in the dentate gyrus, thus impairing the hyppocampus-dependent learning and memory abilities.

In order to reverse the negative neuroplasticity to a positive one, one must be self conscious of what he is doing and break the cycle of psychological and physiological excitation by enhancing proper modulations on certain conversions.

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A constant blasting of the tissues and nerves with seminal fluids will result in immune suppression, inflammation, hypersensitivity, and infertility (due to the toxic effects of the inflammatory mediators on the sperm).

The seminal fluid neuro-immune qualities are essential to establish pregnancy. The prostaglandins and cytokines will bind into the target cells’ receptors in the cervix and uterus, which in turn will activate the pro-inflammatory response and cytokines. Semen will also modulate the neutrophil influx into the uterine lumen.

Poor semen may cause vaginal yeast infection, vulvodynia, vaginosis, or allergic responses in a woman’s vagina. The probability will be greater if the concentration of anti-inflammatory prostaglandins E1 and E3 and cytokines is low and is not capable to balance the inflammatory responses. Rough sex may also contribute to similar reactions due to the mechanical stimulation of cox-2 expression for additional prostaglandin E2 release.

Semen should not be fully discharged through multiple ejaculations. Resident semen into the seminal vesicles is needed to restore brain, nervous and testicular blood function, and proper blood circulation.

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The problem is the orgasmic wave energy has to pass through the periodical structure of the spinal cord which produces resonant (Bragg’s) reflection of the orgasmic wave train. That is, only a small amount of orgasmic wave energy can reach the brain. Generally speaking, to repower the brain function upon ejaculation, one has to accumulate a lot of sexual energy before orgasm.

Sex and masturbation are different in nature. In sex, one extracts sexual energy from a partner to power the penis to maximum size (that is when one feels the penis going numb or semi-numb with a massive erection). When orgasm occurs, contraction of the prostate muscle sends a powerful orgasmic wave back to the brain that stimulates the central nervous system and endocrine organs – adrenal cortexes, the pituitary, and testicles. After an enjoyable sexual encounter one will be surprised to find out that is not feeling very exhausted or tired. This is because the endocrine system has been re-powered by the massive orgasm. Masturbation usually cannot help one achieve that kind of recharge.

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Here is how to reduce masturbation:

• Eat more nuts and seeds – they usually contain L-Arginine and Isoflavones (the plant estrogen for anticancers and antitumors, and the liver function enhancers), that help cool down the prostate.
• Eat more fresh vegetables and fruits for more anticancerous plant hormones, anti-oxidants, vitamins, and minerals.
• Exercise to consume the excessive testosterone elsewhere in the body, rather than burn it into DHT via masturbation.
• Reduce the intake of beef and dairy products (which may be hormone polluted). Red meat traps too much hormone-polluted blood. The synthetic hormones in the red meat and dairy products lower the onset age of masturbation or sexual activities.

As for the psychological part:

• Decide whether your masturbation is a cause for concern.
• Distract yourself.
• Isolate the cause that makes you masturbate.
• Alter thought patterns.
• Change your habits.
• Understand that this is a chemical addiction, not just a harmless habit.

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Here is a list of the most common causes for premature ejaculation:

• Using Kegel Exercises to support the erection, which involves the PC muscles.
• Prostate PC muscles fatigue.
• Poor blood circulation, leading to trapped excessive DHT, norepinephrine, epinephrine, glutamate and histamine.
• Prostate abrasion and fast-ejaculation training.
• Excessive norepinephrine, epinephrine, histamine, and glutamate which lead to nervous toxicity, performance anxiety and penile hypersensitivity.
• Drug abuse – either street or medication drugs.
• Parasympathetic, Serotonin and GABA nervous control disorders.
• Erectile dysfunction.
• Penile, testicle or prostate surgery.
• Excessive inflammatory hormone prostaglandin E2 in the bloodstream, penis, semen, prostate or even your partners vagina.
• Excessive semen accumulation in the seminal vesicles, which exerts pressure against the prostate and induces pelvic congestion and pain.
• Long-term semen retention or abstinence, leading to excessive prostaglandin E2 and/or excessive testosterone.
• Excessive oxytocin in the bloodstream.
• Excessive or insufficient dopamine nervous excitation, associated with the hypothalamic-pituitary-testicular axis and thyroid functioning.
• Excessive or insufficient testosterone and DHT, associated with penile erectile nervous stimulation and inflammatory prostaglandin E2 production.
• Liver functional disorders, affecting the abnormal syntheses of the androgen hormones, thyroid hormones, and neurotransmitters.
• Excessive or insufficient testosterone and DHT, associated with penile erectile nervous stimulation and inflammatory prostaglandin E2 production.
• Pineal gland disorders or melatonin deficiency (sleeping disorder), associated with the recharging of the parasympathetic nervous system during sleeping, the pituitary hGH production, and the serotonin, GABA and norepinephrine nervous function.
• Neuro-endocrine disorders.
• Concentration of ions (Na-K, Cl) and permeability characteristics of the nervous cell membrane.
• Genetic Tetrahydrobiopterin (BH4) deficiency, which will lead to dopamine and serotonin nervous disorders.

Chronic stimulation of sex organs can lead to over-production of a-MSH. It also traps excessive a-MSH in certain areas of the skin, which may result in extra skin darkness, particularly in eye cycles, labia minors, and penile foreskin. Chronic over-masturbation also leads to over-reactive or also called over-trained prostate, PC muscles, and bulbourethral glands.

Destruction of serotonin and GABA nervous control, exhaustion of the hypothalamus-pituitary-adrenal and testicular axis and liver system results in an unbalanced release of pro-opinomelanocotin (POMC) peptides, such as AdrenoCorticoTropic Hormone (ACTH), endorphins, a-Melanocyte-Stimulating Hormone (a-MSH), and Lipotropin Hormone (LPH). Also, prostate abrasion, excessive inflammatory hormone prostaglandin E2 production, excessive stress hormones cortisol and epinephrine for performance anxiety, parasympathetic and sympathetic erectile nervous disorders, excessive use of PC muscles, and precum/semen leakage will be observed. When the serotonin, GABA, endorphrin, cortisol, and/or a-MSH fail to modulate the dopamine – norepinphrine conversion and the psychological stressors norepinephrine/epinephrine-induced inflammatory hormone prostaglandin E2 production, one may observe more than one of the following responses to sexual stimulation:

• Excessive dopamine-norepinephrine induced prostaglandin E2 for a core temperature rise (over-heating or “sex fever”) in the brain, spine, adrenal glands and prostate – the sympathetic nervous “Fight and Flight” responses.
• Prostaglandin E2 over-excited penile and prostate nerves for penile and prostate hypersensitivity.
• Excessive prostaglandin E2 induced prostate and bulbourethral inflammatory responses and over-heating for precum and semen leakage, plus instant ejaculation.

Premature-ejaculation’s most common causes, including drugs, surgery, genetic disorders, and other organ functional disorders.

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Over-masturbation/ejaculation harms the parasympathetic/sympathetic nervous function on the erectile mechanism with the flooding of excessive stress and inflammatory hormones. Excessive testosterone – DHT conversion, excessive prostaglandin E2 production, and excessive precum release are observed through the over-excitatory oxytocinergic nervous function due to the weak serotonin-GABA nervous modulation.

PC exercises or sexual stimulation create more precum by stimulating the prostate to produce additional oxytocin, additional testosterone – DHT conversion, and will heat up the seminal vesicles, prostate itself, and the bulbourethral glands.

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Sexual activities with exhausted hypothalamus-pituitary-adrenal-testicular functions will be constantly inducing excessive dopamine-norepinephrine-epinephrine conversion and keep heightened prostaglandin E2 levels in the local tissues and bloodstream.

Excessive dopamine-norepinephrine-epinephrine conversion may result in heightened cortisol and prolactin and deficiency of dopamine and oxytocin, which will delay the post orgasmic recovery. If the dopamine levels remain sufficient, one will experience persistent sexual arousal with sexual exhaustion. The PSAS symptoms may become even worse if high levels of androgen hormones, oxytocin, and histamine are observed.

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